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Doctoral dissertation 1997 Department of Organic Chemistry Arrhenius Laboratory Stockholm University S-106 91 Stockholm Sweden AbstractA computer program, CASPER, for sequence determination of oligosaccharides and regular polysaccharides using NMR-data, has been extended to support multiply branched structures. The program has been modified to allow the use of incomplete experimental data since spectral overlap can be a problem even at high fields. The resulting program was tested and used in the structure determination of the capsular polysaccharide from Klebsiella type K52.Four carboxyethyl-substituted sugars, methyl 4-O-[(R)- and (S)-1-carboxyethyl]-α;-L-rhamnopyranoside and methyl 6-O-[(R)- and (S)-1-carboxyethyl]-α-D-galactopyranoside have been synthesized. The conformational properties of the latter two have been investigated by both NMR spectroscopy and molecular modelling studies. For the NMR-studies stereospecifically deuterated compounds were prepared. © Roland Stenutz 1997 ISBN 91-7153-611-6 |