Solvent classification according to Snyder (1978)

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Common laboratory solvents can be placed in groups with similar chromatographic properties. The classification below is due to Snyder.
L.R. Snyder, J. Chromatogr. Sci. 16 (1978) 223.
Solvent groups (Solvent strength ε0 in parenthesis)

Group 0
cyclohexane (0.04)structure of cyclohexane
cyclopentane structure of cyclopentane
pentane (0.00)structure of pentane
hexane (0.01)structure of hexane
heptane (0.01)structure of heptane
isooctane structure of isooctane
1,1,2-trichlorotrifluoroethane structure of 1,1,2-trichlorotrifluoroethane
Group 1
diethyl ether (0.38)structure of diethyl ether
methyl t-butyl ether structure of methyl t-butyl ether
diisopropyl ether (0.28)structure of diisopropyl ether
dibutyl ether structure of dibutyl ether
tetramethylguanidine structure of tetramethylguanidine
Group 2
methanol (0.95)structure of methanol
ethanol (0.88)structure of ethanol
n-propanol 0.82structure of n-propanol
isopropanol (0.82)structure of isopropanol
n-butanol (0.70)structure of n-butanol
isobutanol structure of isobutanol
tert-butanol 0.70structure of tert-butanol
isopentanol structure of isopentanol
octanol (0.50)structure of octanol
Group 3
N,N-dimethylacetamide structure of N,N-dimethylacetamide
N,N-dimethylformamide structure of N,N-dimethylformamide
N-methylpyrrolidone structure of N-methylpyrrolidone
pyridine (0.71)structure of pyridine
dimethyl sulfoxide (0.62)structure of dimethyl sulfoxide
2-methoxyethanol structure of 2-methoxyethanol
tetrahydrofuran (0.45)structure of tetrahydrofuran
Group 4
acetic acid (>>1)structure of acetic acid
formamide structure of formamide
benzyl alcohol structure of benzyl alcohol
Group 5
n-butyl chloride structure of n-butyl chloride
dichloromethane (0.42)structure of dichloromethane
ethylene chloride (0.49)structure of ethylene chloride
tricresyl phosphate structure of tricresyl phosphate
Group 6
acetone (0.56)structure of acetone
acetonitrile (0.65)structure of acetonitrile
ethyl acetate (0.58)structure of ethyl acetate
butyl acetate structure of butyl acetate
1,4-dioxane (0.56)structure of 1,4-dioxane
glyme structure of glyme
methyl ethyl ketone (0.51)structure of methyl ethyl ketone
methyl isoamyl ketone structure of methyl isoamyl ketone
methyl isobutyl ketone structure of methyl isobutyl ketone
methyl n-propyl ketone structure of methyl n-propyl ketone
propylene carbonate structure of propylene carbonate
aniline (0.62)structure of aniline
nitromethane (0.64)structure of nitromethane
Group 7
benzene (0.32)structure of benzene
toluene (0.29)structure of toluene
o-xylene structure of o-xylene
nitrobenzene structure of nitrobenzene
chlorobenzene (0.30)structure of chlorobenzene
1,2-dichlorobenzene structure of 1,2-dichlorobenzene
1,2,4-trichlorobenzene structure of 1,2,4-trichlorobenzene
diphenyl ether structure of diphenyl ether
Group 8
m-cresol structure of m-cresol
chloroform (0.40)structure of chloroform
dodecafluoroheptane structure of dodecafluoroheptane
water >0.95structure of water
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